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Sunday, July 12, 2020

Dr. Aaronson's Must Not Miss: Additional Benefits of the SGLT2 Inhibitors and Treating Diabetes 6.12.2020

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What are 2 additional benefits of the SGLT2 inhibitors?

What are 2 additional benefits of the SGLT2 inhibitors in addition to blood sugar control?

Note: your primary provider or endocrinologist will prescribe these medications for you. We nephrologists collaborate with your team to help prevent worsening chronic kidney disease. It's important to know the different providers' roles in the management of your care.
In patients with diabetes mellitus and chronic kidney disease, medications in the SGLT2 (Sodium-glucose Cotransporter-2) class of medications, medications that include dapagliflozin (also called Farxiga), empagliflozin (also called Jardiance), and Canagliflozin (also called Invokana) can provide 2 additional benefits besides sugar control. These benefits include:

  1. Weight loss: patients can excrete up to 100 grams of glucose per day in the urine. That amount equates to around 300 calories a day of sugar. That's equivalent to around 2 cans of soda pop.
  2. The SGLT2 inhibitors decrease the risk of kidney disease and protect patients against acute kidney injury in the future.

When tolerated, the SGLT2 inhibitors are frequently combined with metformin. If you have more interest in this modality of therapy, ask your doctor for more information.

Recommended reading: SGLT2 inhibitors for the prevention of kidney failure in patients with Type 2 diabetes.